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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERBB2
All Species:
13.64
Human Site:
Y685
Identified Species:
30
UniProt:
P04626
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04626
NP_001005862.1
1255
137910
Y685
R
Q
Q
K
I
R
K
Y
T
M
R
R
L
L
Q
Chimpanzee
Pan troglodytes
XP_001156546
1212
134545
R679
R
R
H
I
V
R
K
R
T
L
R
R
L
L
Q
Rhesus Macaque
Macaca mulatta
XP_001090430
1255
138107
Y685
R
Q
Q
K
I
R
K
Y
T
M
R
R
L
L
Q
Dog
Lupus familis
XP_533073
1595
175523
R1065
R
R
H
I
V
R
K
R
T
L
R
R
L
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
P70424
1256
138561
Y686
R
R
Q
K
I
R
K
Y
T
M
R
R
L
L
Q
Rat
Rattus norvegicus
P06494
1257
138814
Y687
R
R
Q
K
I
R
K
Y
T
M
R
R
L
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507339
1187
132966
R652
R
R
H
I
V
R
K
R
T
L
R
R
L
L
Q
Chicken
Gallus gallus
P13387
703
77409
A188
P
L
T
V
L
D
F
A
S
N
L
S
S
C
P
Frog
Xenopus laevis
Q91694
985
109711
V469
E
P
E
R
A
N
G
V
I
L
E
Y
E
V
K
Zebra Danio
Brachydanio rerio
NP_956413
1275
140811
E678
Q
K
H
Q
K
K
K
E
T
I
R
R
R
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P04412
1426
159700
L731
E
Q
G
S
L
K
P
L
A
G
R
A
V
C
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
98.2
39.5
N.A.
87.6
87.9
N.A.
48
27.1
22.6
54.2
N.A.
30.5
N.A.
N.A.
N.A.
Protein Similarity:
100
63.1
98.5
51.7
N.A.
92
91.8
N.A.
62.8
36.1
36.5
66.8
N.A.
45.9
N.A.
N.A.
N.A.
P-Site Identity:
100
60
100
60
N.A.
93.3
93.3
N.A.
60
0
0
40
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
80
100
80
N.A.
100
100
N.A.
80
13.3
33.3
73.3
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
10
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
19
0
10
0
0
0
0
10
0
0
10
0
10
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
10
0
0
10
0
0
0
0
0
% G
% His:
0
0
37
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
28
37
0
0
0
10
10
0
0
0
0
0
% I
% Lys:
0
10
0
37
10
19
73
0
0
0
0
0
0
0
10
% K
% Leu:
0
10
0
0
19
0
0
10
0
37
10
0
64
73
0
% L
% Met:
0
0
0
0
0
0
0
0
0
37
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% N
% Pro:
10
10
0
0
0
0
10
0
0
0
0
0
0
0
10
% P
% Gln:
10
28
37
10
0
0
0
0
0
0
0
0
0
0
73
% Q
% Arg:
64
46
0
10
0
64
0
28
0
0
82
73
10
0
10
% R
% Ser:
0
0
0
10
0
0
0
0
10
0
0
10
10
0
0
% S
% Thr:
0
0
10
0
0
0
0
0
73
0
0
0
0
0
0
% T
% Val:
0
0
0
10
28
0
0
10
0
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
37
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _